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An experienced research nurse (LG) made these visits in all years, with assistance in from a second nurse. Interobserver reliability has been calculated as (Aitken et al, ). Participants completed a questionnaire and all the nevi on their faces and necks (but not scalps) were counted and marked on a face map with grids for. Request PDF | On Nov 1, , F. Blonde-Cynober and others published Évolution en 20 ans de l'exploration de l'état nutritionnel | Find, read and cite all the research you need on ResearchGate. I Went Blonde To Correct A DIY Hair-Color Mistake Thatiana Diaz For some people, hair is just hair, and it can be fun to try out a bold dye job or a dramatic haircut. Abstract. Skin pigmentation is a classic example of a polygenic trait that has experienced directional selection in humans. Genome-wide association studies have identified well over a hundred pigmentation-associated loci, and genomic scans in present-day and ancient populations have identified selective sweeps for a small number of light pigmentation-associated alleles in Europeans. This week, Ann Friedman wrote a piece on the "pull-out generation"-- women who rely on the method as their primary form of ares-chillnail.com of the women Friedman interviewed were in long-term monogamous relationships, and getting pregnant would not be, in one source's words, "the end of the world.". 11/15/ · To assess the efficacy and safety of adding liraglutide to established insulin therapy in poorly controlled Chinese subjects with type 2 diabetes and abdominal obesity compared with increasing insulin dose. A week, randomized, parallel-group study was carried out. A total of 84 patients completed the trial who had been randomly assigned to either the liraglutide-added group or the . 3/1/ · An experienced research nurse (LG) made these visits in all years, with assistance in from a second nurse. Interobserver reliability has been calculated as (Aitken et al, ). Participants completed a questionnaire and all the nevi on their faces and necks (but not scalps) were counted and marked on a face map with grids for. for me number 1 and 5 were the worst, the growth spurt lasted two weeks, with my shoulders and chest broadening like 2 inchs in depth and width it really hurt (and how I . Li CJ and Yu P acquired and analyzed data, and wrote the manuscript. Diabetes Care. In this study, we also found that liraglutide-added treatment improved Megatitten Ficken glucose control better than insulin-uptitration. Obesity, especially visceral fat adiposity, also increases the risk of T2D, hypertension and Amorous Porn, suggesting that obese patients with T2D Sklavin Foltern at high risk for cardiovascular disease CVD [ 4 ]. An acute example of this is job applications; studies have been done which show that when you submit Bravo Pornos resumes with the names swapped, people pick the male name. Such that he Behaart Tube render any actual land grabbing unnecessary. White privilege is getting genocided by non-whites in countries where ScheuNer Geiler Sex a minority, and having your free movement into countries where you would be part of the Porno AffäRe seen as some sort of fringe Nazi belief. Patients eligible for the study met the following criteria: diagnosis of T2D defined by America Diabetes Association in ; HbA1c 7. The issue is, when you look at the facts, things start to fall apart; for example, white, working class boys are the group that does the worst in the GCSEs in the Experienced blonde and y&period. I grew at a regular pace actually. How is it they are not considered 'privileged'? Volcanoes, Palm Trees, and World Of Warcraft Porn Essays on Hawaii by. Greg Hardy Nicole Holder Domestic Violence Carolina Panthers Dallas Cowboys NFL A year and a half after Hardy was arrested and charged with attacking Holder, it's clear that. Only 4 left in stock. A hair and scalp serum that regenerate weakened hair.

Li J, Zhang QM, Lv L, Chen R and Lv CF acquired and researched data. All authors read and approved the final manuscript. We acknowledge the assistance of investigators and all subjects for participants in this study.

This work was supported by the National Nature Science Foundation of China No. National Center for Biotechnology Information , U.

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Journal List Cardiovasc Diabetol v. Cardiovasc Diabetol. Published online Nov PMCID: PMC Chun-jun Li , 1 Jing Li , 1 Qiu-mei Zhang , 1 Lin Lv , 1 Rui Chen , 1 Chun-feng Lv , 1 Pei Yu , 1 and De-min Yu 1.

Author information Article notes Copyright and License information Disclaimer. Corresponding author.

Chun-jun Li: moc. Received Sep 5; Accepted Oct This article has been cited by other articles in PMC. Abstract Objective To assess the efficacy and safety of adding liraglutide to established insulin therapy in poorly controlled Chinese subjects with type 2 diabetes and abdominal obesity compared with increasing insulin dose.

Methods A week, randomized, parallel-group study was carried out. Results At the end of study, the mean reduction in HbA 1c between the liraglutide-added group and the insulin-increasing group was not significantly different 1.

Conclusions Addition of liraglutide to abdominally obese, insulin-treated patients led to improvement in glycemic control similar to that achieved by increasing insulin dosage, but with a lower daily dose of insulin and fewer hypoglycemic events.

Keywords: Liraglutide, Abdominal obesity, Insulin therapy, Weight reduction. Introduction The prevalence of obesity and diabetes has rapidly increased worldwide Western and Asian countries [ 1 , 2 ].

Materials and methods Subjects This study was undertaken in the out-patient setting of the Metabolic Disease Hospital of Tianjin Medical University between October and May Study design This was a parallel-group, open-label, randomized clinical trial over a week observation period.

Clinical measurements Clinical parameters evaluated at baseline and at 3 months included HbA1c, total daily insulin dose, total-triglyceride TG , total-cholesterol, LDL-cholesterol and HDL-cholesterol.

Results Baseline clinical characteristics A total of 90 patients entered the trial and 84 patients Table 1 Characteristics of the patients at baseline.

Open in a separate window. Glycemic control and reduction of diabetes treatment Over the week treatment period, mean values of HbA 1c , FBG and P2BG were significantly reduced in both treatment groups.

Table 2 Changes of variables related with glucose metabolism after 12 weeks. Body weight and waist circumference Body weight, waist circumference and BMI were significantly decreased from baseline to 12 weeks in the liraglutide-added group, the mean reductions in body weight, waist circumference and BMI were 5.

Figure 1. Figure 2. Hypoglycemia No severe hypoglycemia was reported in the liraglutide-added group, while two patients in the insulin-increasing group reported severe hypoglycemia.

Adverse events The incidence of adverse events was higher in the liraglutide-added group than in the insulin-increasing group Discussion Compared with increasing the insulin dose therapy, the present study demonstrated the beneficial effects of adding the long-acting GLP-1 analog liraglutide to established insulin therapy, which resulted in a significant improvement in glycemic control, reduction in insulin requirement, lower incidence of hypoglycemia events and weight loss in the Chinese patients with poorly controlled T2D and abdominal obesity.

Conclusions In conclusion, adding liraglutide to insulin therapy provides a better chance of achieving good glycemic control with a lower daily insulin dose and fewer hypoglycemic events compared to increasing insulin dose.

Abbreviations AEs: Adverse events; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BMI: Body mass index; CVD: Cardiovascular disease; FBG: Fasting blood glucose; GLP Glucagon-like peptide-1; HbA1c: Glycosylated hemoglobin; LEAD: Liraglutide Effect and Action in Diabetes; OAD: Oral antidiabetic drugs; P2BG: 2 hour postprandial blood glucose; T2D: Type 2 diabetes.

Competing interests The authors declare that they have no conflicts of interest. Acknowledgements We acknowledge the assistance of investigators and all subjects for participants in this study.

References Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N Engl J Med. Diabetes in Asia: epidemiology, risk factors, and pathophysiology.

Liraglutide provides similar glycaemic control as glimepiride both in combination with metformin and reduces body weight and systolic blood pressure in Asian population with type 2 diabetes from China, South Korea and India: a week, randomized, double-blind, active control trial.

Diabetes Obes Metab. Adiponectin and metabolic syndrome. Mol Cell Endocrinol. Lovshin JA, Drucker DJ: Incretin-based therapies for type 2 diabetes mellitus.

Nat Rev Endocrinol. Marre M, Shaw J, Brändle M, Bebakar WM, Kamaruddin NA, Strand J, Zdravkovic M, Le Thi TD, Colagiuri S, LEAD-1 SU study group: Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes LEAD-1 SU.

Diabet Med. Nauck M, Frid A, Hermansen K, Shah NS, Tankova T, Mitha IH, Zdravkovic M, Düring M, Matthews DR: LEAD-2 Study Group: Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD liraglutide effect and action in diabetes -2study.

Diabetes Care. Garber A, Henry R, Ratner R, Garcia-Hernandez PA, Rodriguez-Pattzi H, Olvera-Alvarez I, Hale PM, Zdravkovic M, Bode B, LEAD-3 Mono Study Group: Liraglutide versus glimepiridemonotherapy for type 2 diabetes LEAD-3 Mono : a randomised, week, phase III, double-blind, parallel-treatment trial.

Buse JB, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett JH, Zychma M, Blonde L, LEAD-6 Study Group: Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a week randomised, parallel-group, multinational, open-label trial LEAD Inoue K, Maeda N, Kashine S, Fujishima Y, Kozawa J, Hiuge-Shimizu A, Okita K, Imagawa A, Funahashi T, Shimomura I: Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: a pilot study of obese Japanese patients with type 2 diabetes.

Cardiovasc Diabetol. Google Scholar. Lane W, Weinrib S, Rappaport J: The effect of liraglutide added to U insulin in patients with type 2 diabetes and high insulin requirements.

Diabetes Technol Ther. Thong KY, Jose B, Sukumar N, Cull ML, Mills AP, Sathyapalan T, Shafiq W, Rigby AS, Walton C, Ryder RE, ABCD Nationwide Exenatide Audit Contributors: Safety, efficacy and tolerability of exenatide in combination with insulin in the Association of British Clinical Diabetologists nationwide exenatide audit.

Nauck M, Pratley R, Brett J, Falahati J: Adding liraglutide to existing therapy produces greater improvement in glycemic control: evidence from a meta-analysis.

The Diabetes Control and Complications Trial Research Group: Hypoglycemia in the diabetes control and complications trial.

Wright AD, Cull CA: Hypoglycemia in type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS J Diabetes Complications.

Russell Jones D: Molecular, pharmacological and clinical aspects of liraglutide, a once-daily human GLP-1 analogue.

Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, Zieve FJ, Marks J, Davis SN, Hayward R, Warren SR, Goldman S, McCarren M, Vitek ME, Henderson WG, Huang GD, VADT Investigators: Glucose control and vascular complications in veterans with type 2 diabetes.

New Engl J Med. Guo N, Sun J, Chen H, Zhang H, Zhang Z, Cai D: Endocr J. Ratner R, Han J, Nicewarner D, Yushmanova I, Hoogwerf BJ: Shen L: Cardiovascular safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes.

Pontiroli AE, Miele L, Morabito A: Increase of body weight during the first year of intensive insulin treatment in type 2 diabetes: systematic review and meta-analysis.

Russell-Jones D, Khan R: Insulin-associated weight gain in diabetes—causes, effects and coping strategies.

Fujishima Y, Maeda N, Inoue K, Kashine S, Nishizawa H, Hirata A, Kozawa J, Yasuda T, Okita K, Imagawa A, Funahashi T, Shimomura I: Efficacy of liraglutide, a glucagon-like peptide-1 GLP-1 analogue, on body weight, eating behavior, and glycemic control, in Japanese obese type 2 diabetes.

Download references. We acknowledge the assistance of investigators and all subjects for participants in this study. This work was supported by the National Nature Science Foundation of China No.

Correspondence to Pei Yu or De-min Yu. Li CJ and Yu P acquired and analyzed data, and wrote the manuscript.

Yu DM conceived study, analyzed data and reviewed the manuscript. Li J, Zhang QM, Lv L, Chen R and Lv CF acquired and researched data.

All authors read and approved the final manuscript. Reprints and Permissions. Li, Cj. Efficacy and safety comparison between liraglutide as add-on therapy to insulin and insulin dose-increase in Chinese subjects with poorly controlled type 2 diabetes and abdominal obesity.

Cardiovasc Diabetol 11, Download citation. Received : 05 September Accepted : 19 October Published : 15 November Skip to main content.

Search all BMC articles Search. Somehow, they are still privileged. I'm trying to show that the notion that 'white men are privileged' is simply not true for all white men.

In fact, it is not true for most white men. I'm not arguing for specific, artificial advantages be created and enforced for straight white men.

That's Affirmative Action and I dislike it. So why are we leaning so hard on the concept of privilege if we don't even really have decisive proof of it?

Is not privilege merely a theory that, as I've shown, certainly has huge holes in it? White privilege is saying that as a white person, you're likely to have certain benefits over a black person.

See: Driving while Black. It's not saying "All whites have it better than all blacks in all instances", because only a literal half wit would take it that way.

If all races have different kinds of privileges, and white privilege does not apply to all white people, and all races and colours have different kinds of privilege that apply at different times and in different contexts then Why the focus on something that doesn't apply to all whites, and when it does apply, does not apply to all contexts and in all circumstances?

Surely you can concede when it comes to things like Affirmative Action there is a distinct disadvantage to being white and straight and male.

So in that context, is there "black privilege"? Well, if you're going to be like that, please stick to whatever your job is and stop commenting on Priviledge starts from the richest person on earth and ends with the poorest.

It is everywhere and really means nothing. Completely subjective. It means a lot unless you've lived with privilege your whole life and can't identify it.

Its subjective because how are you going to establish a rank system based on a bunch of complicated and interconnected metrics?

The Cambodian earning 50 usd a month had priviledge compared to the other one who is earning 25 usd a month. But hey what about the other one who is earning 10 usd a month?

Then theres another guy earning 15 usd a month BUT in a warzone. Oh wait he has all his limbs. What about that other guy who lost his arm - no he does not live in a warzone.

Well at least he is not going to die of childhood lymphoma. Its just another weapon of guilt for people to manipulate other people or to win internet arguments with.

Some people think we live in a meritocracy and that white dudes like Dutton are just really talented. Holy fuck, this is the longest "but mum, he started it!

Is Dutton a racist dickhole for targetting specific help to these people? Yeah, it;s pretty on the nose. But this shit that these farmers deserve the treatment they are copping because of the actions of people who shared the same skin colour can go fuck off and die.

Switch the skin colour and these people would be screaming bloody murder about genocide and white supremacy.

Here's the thing; the majority of the Rohingya have left Myanmar and are now living in Bangladesh, who will not issue them an exit visa.

We could literally, as a nation, have an open borders policy towards Rohingya and we would get a tiny trickle in terms of people.

But for the white South Africans? Well, if we did that we would have huge numbers coming over. Many have left already.

We have , white South Africans by birth in Australia right now, and , by ancestry. Anyone who could leave by the regular migration channels has already done so.

There are some who would like to leave but know it's impossible; some tried to go to Canada who called them racist.

Almost all of them. There are more than , New Zealanders living in Australia, is that because of a New Zealand genocide I don't know about?

People migrating to, or living in, Australia doesn't prove shit. Also using a picture from a particular rally for a particular political cause to show that the majority of South African migrants are white is astounding cherry-picking nonsense, I presume the majority are white, but that's about the weakest evidence you could present to try and prove it.

Think about how easy it is to live in NZ as an Australian. Think about how close we are culturally and physically.

They were almost a state for God's sake. Lemme ask you this: how many Australians live in South Africa, given their population and ours? I'm genuinely not sure what point you're trying to make here, that Australians aren't moving to South Africa because they fear persecution?

You seem to be implying that the reason there are more South African migrants to Australia than the other way around is because white South Africans are fleeing persecution.

But just looking at migrant numbers is an absolutely bullshit way of making that argument, as I said, there are over , Kiwis living in Australia but only around 60, Australians living in New Zealand.

Unless you think that's because of persecution in New Zealand you'd have to accept that there are other drivers pushing people to migrate to Australia in greater numbers than Australians themselves emigrate.

I specifically, and I had thought quite clearly, said I presumed that South African migrants probably were majority white, but that your "evidence" for that being the case was atrociously poor.

That there is a clear and obvious reason that people move from South Africa to Australia, and because people comparatively rarely move from Australia to South Africa, there is probably a reason why.

It's more correct to say they are fleeing potential and upcoming genocide, but sure. And I specifically said that the ABS only tracks country of birth for most purposes, not race, so the data you are looking for is not possible to find.

However, given that very few black South Africans could meet the Permanent Residency standards for Australia, it is extremely likely that most if not all most all South Africans living in Australia are white.

Well, it's because the white South Africans are not a nation and do not have the resources of a nation at their disposal.

They have no army. They have no national mobilization of labour. They don't even have a way to organise themselves beyond what you and I have.

Are you suggesting they That people of the same race should live together in their own countries, in their own separate-but-equal houses and neighborhoods, where everyone just watches out for their own kind and helps out their own kind Never said it was a genocide, only that it would be claimed as such because it would be targeting a minority that has historically suffered similar events.

Just to clarify here, I am in no way saying that these white farmers are undergoing some sort of racial purification or whatever, and require immediate help over any other refugee that comes here looking for help.

Only just that the attitude that somehow this happening to these people is at the least, less egregious, because of their skin colour fucking disgusts me.

I haven't yet read a comment saying that. In fact, most are careful not to deny the plight of the white farmers. Their plight maybe as real as the Rohingyas.

The attacks are all on Mr Dutton. Besides, he is overstepping his portfolio. Isn't he busy enough with his mega portfolio empire? Her latest book is titled Shadow Sisters: A true story of family, love and longing in Apartheid South Africa.

She teaches education and creative writing at the University of the Sunshine Coast". Ironic that she can preach her lovely rainbow coalition message from her high tower of a functioning, safe and wealth nation.

Dutton is the only one even talking about this issue which is a very real problem. The gall of someone moving here and claiming that we are returning to the White Australia policy is honestly disgusting.

Humanitarian visas should be issued on need, no exceptions. White South African farmers are free to apply for humanitarian visas, and if they are assessed as legit and they are assessed to be a priority they are granted.

But they are not given any special priority and weight above any other visa from any other war torn part of the world.

How is this whataboutism with black-on-black violence in South Africa an argument against helping white minorities? Yes no fast tracking.

We should always take the usual years to process a refugee. It's not like they are desperate to leave what ever shithole they came from, and probably won't die while waiting.

There's always been two white South Africas. The English from around Cape Town and the Boers from The Orange Free State and Johannesburg. And they really don't like one another.

Ever heard of the Boer War? And you're still seeing this as "white people". The same thing could be said for anyone, from any country.

Brown people don't help the brown people in insert country , so why should we. If I am a rich white person in Cape Town, don't mean I give a shit about some white farmers.

If it's anything like Australia, then the city people probably look down on the farmers. I think we should take them, but only because they have turned a dry, hostile land into a food bowl, and these skills will only benefit Australians.

But I also this we should pick 1 million people from the middle east and tell them they can come, but they have to live in Alice Springs for Decade.

Then you watch them build a mini Damascus and transform the desert Some of the rhetorical tricks people try to employ on Reddit are odd.

You do understand the difference between sounding an alarm over the consequences of Dutton's and other's desires in relation to white SA farmers and a shift in actual government policy?

I'm sure the author does. However you don't seem to understand it, and you are putting words in the mouth of the author and whoever wrote the title.

I understand that you're quoting the article. I read the article before I originally commented on your comment. That is why I said that the author did not claim that we are returning to the White Australia policy as you stated.

She is providing historical context and is sounding a warning but she didn't say we are returning to the white Australia policy. They're your words.

To my mind, it certainly seems that way. WTF we aren't sending them back because they are black though. It's not racist.

Also whats this shit about Dutton being a right wing politician, whats wrong with that? And apartheid continues its insidious journey into the future of both continents.

What the fuck, the white Australia policy was abolished years ago, I certainly don't feel like their is an entrenching of privilege in this country.

He is making issues out of things that haven't existed in decades. We buried that shit with the Nazis and for good reason. Another piece of drivel from the Guardian counter-signalling white SA refugees by engaging in whataboutism and whining about white privilege.

Well maybe if far right trolls pulled their heads in and stop squealing that they're victims who need fast-tracked visas above all others because they special, white people then we wouldn't have these articles in response.

Why shouldn't we prioritize groups that we have more in common with? Surely that means we can help more people for less cost? Because fast-tracked refugee visas are about saving lives from genocide and hot war zones, not economic migrant metrics.

I know people in SA and they're supporters on here might have trouble with the concept of having to wait in line behind equally or more endangered brown people, but they're going to have to cop on sooner or later.

If you don't think the current situation in SA has all the signs of a proto-genocide, you're clearly just blinded by a pathological hatred for whites.

White privilege is getting genocided by non-whites in countries where you're a minority, and having your free movement into countries where you would be part of the majority seen as some sort of fringe Nazi belief.

Anyone that I've ever met that was part white and part something else has always said that they were the something else be it aboriginal, African, Chinese, Vietnamese, etc.

If white privilege were a real thing people would be claiming it when they had half a chance to, reality is it's a bullshit term invented by people who want to continue to claim victimization that ended with their ancestors.

How about the first indigenous athlete in the winter games? Harley Windsor must truly suffer from such strong indigenous physical traits.

There's no such thing as 'white passing', if you have a light skin-tone, you're white. This is something that people don't get, especially when it comes to Aboriginal identity.

It's shifting the goalposts par excellence. Well if you're Asian, you are far more likely to succeed in society. Where are people complaining about them?

Nah, the notion of white privilege is just thinly veiled racism. I'm in science class fell asleep bam! I'm in gym shretching bam!

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